Existing chemical could help treat alcohol use disorder. A new study suggests that a commercially available chemical could influence positively on a pathway involved in both mood disorders and alcohol use disorder (AUD).
A person with AUD feels strong craving for alcohol as well as fails to limit the consmuption of alcohol. The National Institute on Alcohol Abuse and Alcoholism estimates that around 16 million people in the United States have AUD.
In addition, according to the National Institute of Mental Health, there is around 9.7 percent of adults in America with mood disorders – including depression and bipolar disorder – between 2016 and 2017.
Pervious studies have shown an association between AUD and mood disorders. They have explained that drinking alchol at high amount can produce depression-like symptoms.
In a new study, researchers from the Oregon Health & Science University in Portland studied a zinc-binding receptor called G-protein coupled receptor 39 (GPR39). They wanted to search for unique of approaching AUD. Their findings now features in the journal Neuropsychopharmacology.
Further, the team used a widely available chemical called TC-G 1008 to activate GPR39. They fed the compound to mice and observed that it reduced the level of alcohol that the mice drank.
“The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder,” said senior author Rita Cervera-Juanes, Ph.D.
The researchers explains that the levels of activity and inhibition in the nucleus accumbens led TC-G 1008 to reduce the level of alcohol consumption.